HORDB

ID: hor002126
Uniprot ID: P06306
Protein name: Insulin A chain
Gene name: INS
Organism: Felis catus (Cat) (Felis silvestris catus)
Family: Insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Felis (genus), Felinae (subfamily), Felidae (family), Feliformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction; GO:0042593 glucose homeostasis; GO:0050714 positive regulation of protein secretion
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: GIVEQCCASVCSLYQLEHYCN
Length: 21
Propeptide: MAPWTRLLPLLALLSLWIPAPTRAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREAEDLQGKDAELGEAPGAGGLQPSALEAPLQKRGIVEQCCASVCSLYQLEHYCN
Signal peptide: MAPWTRLLPLLALLSLWIPAPTRA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: INSR
Target Unid: A0A2I2UE37
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002126_AF2.pdb

hor002126_ESM.pdb

Mass:	271963	Formula:	C99H152N26O33S4
Absent amino acids:	DFKMPRTW	Common amino acids:	C
pI:	4.25	Basic residues:	1
Polar residues:	10	Hydrophobic residues:	6
Hydrophobicity:	33.33	Boman Index:	-1237
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	88.1
Instability Index:	2435.24	Extinction Coefficient cystines:	3230
Absorbance 280nm:	161.5